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Table 4 Relative levels acylcarnitines across classes within Acute Lung Injury Registry cohort

From: Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome

Metabolite

Airway controls (N = 42)

Class 1 ARDS (N = 44)

Class 2 ARDS (N = 44)

Fold change Class 1 vs. controls

P-value

Fold change Class 2 vs. controls

P-value

Fold change Class 2 vs Class 1

P-value

Propionylcarnitine [Median, IQR]

0.49 [0.24, 0.80]

0.79 [0.41, 1.21]

0.65 [0.48, 1.08]

1.62

0.14

1.32

0.027

0.82

1.00

Butyrylcarnitine [Median, IQR]

0.26 [0.15, 0.45]

0.40 [0.26, 0.87]

0.60 [0.32, 0.88]

1.52

0.0012

2.29

< 0.0001

1.51

1.00

Isovalerylcarnitine [Median, IQR]

0.14 [0.078, 0.18]

0.25 [0.12, 0.40]

0.28 [0.15, 0.39]

1.81

0.0017

2.04

< 0.0001

1.13

0.96

Octanoylcarnitine [Median, IQR]

0.15 [0.059, 0.25]

0.18 [0.10, 0.32]

0.35 [0.22, 0.54]

1.20

0.29

2.34

< 0.0001

1.94

0.00040

Myristoylcarnitine[Median, IQR]

0.035 [0.023, 0.059]

0.028 [0.022,0.047]

0.033 [0.023,0.062]

0.82

0.49

0.95

> 0.9999

1.16

0.60

  1. Median values are shown for relative amounts (peak area ratio of analyte/internal standard) of metabolites as determined using stable isotope dilution liquid chromatography high resolution mass spectrometry (LC-HRMS). Interquartile range (IQR) is shown for each metabolite with fold-change and P-values among airway controls, Class 1 ARDS, and Class 2 ARDS patients
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Respiratory Research

ISSN: 1465-993X

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