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Table 3 Relative acetylcarnitine and carnitine levels across classes in patients with acute respiratory failure

From: Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome

Metabolite

Airway controls (N = 50)

Class 1 ARDS (N = 50)

Class 2 ARDS (N = 50)

Fold change Class 1 vs. controls

P-value

Fold change Class 2 vs. controls

P-value

Fold Change Class 2 vs Class 1

P-value

Carnitine (C0) [Median, IQR]

2.54 [1.39, 3.46]

2.94 [2.44, 3.88]

3.07 [2.04, 4.63]

1.16

0.21

1.21

0.11

1.04

1.00

Acetylcarnitine (C2) [Median, IQR]

3.51 [2.05, 6.09]

4.30 [2.57, 5.59]

6.08 [3.19, 9.99]

1.23

1.00

1.73

0.0016

1.41

0.016

C2:C0 [Median, IQR]

0.42 [0.33, 0.59]

0.37 [0.28, 0.51]

0.58 [0.43, 0.70]

0.88

0.30

1.38

0.043

1.56

0.0001

  1. Median values are shown for relative amounts (peak area ratio of analyte/internal standard) of metabolites as determined using stable isotope dilution liquid chromatography high resolution mass spectrometry (LC-HRMS). Interquartile range (IQR) is shown for each metabolite with fold-change and P-values among airway controls, Class 1 ARDS, and Class 2 ARDS patients. Relative amounts were compared using the Kruskal–Wallis test with Dunn’s multiple comparisons test. The median ratio of acetylcarnitine to carnitine (C2:C0) is also shown with IQR included. Groups were compared using the Kruskal–Wallis test with P-values as shown
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Respiratory Research

ISSN: 1465-993X

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