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Table 2 Laboratory and clinical data for Acute Lung Injury Registry cohort

From: Serum metabolomic signatures of fatty acid oxidation defects differentiate host-response subphenotypes of acute respiratory distress syndrome

Variable

Class 1 ARDS (N = 50)

Class 2 ARDS (N = 50)

Airway controls (N = 50)

P-value Class 1 vs. Class 2

P-value Class 1 vs. Controls

P-value class 2 vs. Controls

Laboratory parameters

 WBC, median [IQR], × 109 per liter

12.8 [9.8, 17.2]

14.6 [10.4, 19.1]

10.8 [8.4, 15.3]

0.25

0.23

0.025

 Platelets, median [IQR], × 109 per liter

192.0 [139.0, 249.0]

149.5 [70.0, 244.0]

177.0 [113.0, 238.0]

0.14

0.46

0.33

 Hgb, median [IQR], g/dL

9.9 [8.9, 10.9]

10.1 [8.2, 10.7]

11.8 [10.2, 13.5]

0.49

< 0.0001

< 0.0001

 BUN, median [IQR], mg/dL

28.5 [15.0, 45.0]

41.0 [23.0, 54.0]

18.0 [10.0, 26.0]

0.041

0.0009

< 0.0001

 Creatinine, median [IQR], mg/dL

1.0 [0.7, 2.0]

2.6 [1.4, 3.6]

0.9 [0.6, 1.2]

< 0.0001

0.12

< 0.0001

 Glucose, median [IQR], mg/dL

137.0 [106.5, 170.0]

137.0 [118.0, 154.0]

134.0 [107.0, 173.0]

0.71

0.61

0.90

Mechanical ventilation parameters

 PEEP, median [IQR], cm H2O

10.0 [8.0, 12.0]

8.0 [5.0, 12.0]

5.0 [5.0, 5.0]

0.28

< 0.0001

< 0.0001

 Plateau Pressure, median [IQR], cm H2O

26.0 [22.0, 30.0]

25.0 [21.0, 31.0]

16.0 [13.0, 18.0]

0.60

< 0.0001

< 0.0001

Outcomes

 Acute Kidney Injury, N (%)

20 (40.0)

36 (72.0)

11 (22.0)

0.002

0.083

< 0.001

 Duration of intubation, median [IQR], days

11.0 [7.0, 17.0]

7.0 [5.0, 12.0]

4.0 [2.0, 7.0]

0.014

< 0.0001

< 0.0001

 ICU LOS, median [IQR], days

14.0 [9.0, 21.0]

10.5 [7.0, 18.0]

5.0 [4.0, 10.0]

0.069

< 0.0001

< 0.0001

 VFD, median [IQR], days

11.0 [0.0, 20.0]

1.0 [0.0, 22.0]

24.0 [19.0, 26.0]

0.96

< 0.0001

< 0.0001

 Vasopressor Use, N (%)

33 (66.0)

37 (74.0)

8 (16.0)

0.38

< 0.0001

< 0.0001

 30 Day mortality, N (%)

15 (30.0)

17 (34.0)

7 (14.0)

0.83

0.090

0.034

 90 Day mortality, N (%)

18 (36.0)

18 (36.0)

8 (16.0)

> 0.99

0.039

0.039

  1. Pairwise comparisons between groups were analyzed by the Mann–Whitney U test with P-values shown for each comparison. Abbreviations: WBC white blood cell count, Hgb hemoglobin, IQR interquartile range, PEEP positive end-expiratory pressure, LOS length of stay, VFD ventilator-free days
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Respiratory Research

ISSN: 1465-993X

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