Table 2 µCT automatically computed biomarkers
µCT biomarkers of interest | ||||
|---|---|---|---|---|
Name | Description | Unit | Formula | |
Morphological biomarkers | %Normo | Percentage of parenchyma which is normo-aerated. It reflects the number of no/mild lesions | % | Percent voxels in range [− 860, − 435]* |
%Hypo | Percentage of parenchyma which is hypo-aerated. It reflects the number of moderate lesions | % | Percent voxels in range (− 435, − 121)* | |
%Non | Percentage of parenchyma which is non-aerated. It reflects the number of severe lesions | % | Percent voxels in range [− 121, 121]* | |
Tissue | Lung volume without gas | mm3 | \({\mathrm{V}}_{\mathrm{P}02}-\mathrm{FRC}\) | |
Functional biomarkers | \(\%{Gas}_{P01}\) | Percentage of gas volume at the end of inspiration phase (P01) | % | \(\mathrm{Air}\cdot 100/{\mathrm{V}}_{\mathrm{P}01}\) |
\(\%{Gas}_{P02}\) | Percentage of gas volume at the end of expiration phase (P02) | % | \(FRC\cdot 100/{V}_{P02}\) | |
Tidal Volume (TV) | Volume of air exchanged between inspiration and expiration | mm3 | \(\mathrm{Air}-\mathrm{FRC}\) | |