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Fig. 8 | Respiratory Research

Fig. 8

From: Submersion and hypoxia inhibit alveolar epithelial Na+ transport through ERK/NF-κB signaling pathway

Fig. 8

The schematic diagram depicts the potential mechanism about decreased expression of ENaC in AT2 cells during hypoxia. The accumulation of pulmonary edema fluid created a hypoxic environment, which stimulated the phosphorylation of ERK1/2, induced phosphorylation of IκB and NF-κB p65, and promoted nuclear translocation of p65. Proinflammatory cytokines may also affect ENaC activity and expression. Eventually, vectorial Na+ transport was suppressed, leading to edema formation. AT1/2 alveolar type 1/2, ERK1/2 extracellular signal-regulated kinase 1/2, ENaC epithelial sodium channel, HIF-1α hypoxia-inducible factor 1α, IκBα inhibitor κBα, NF-κB nuclear factor κB

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