Fig. 7
From: Submersion and hypoxia inhibit alveolar epithelial Na+ transport through ERK/NF-κB signaling pathway
Hypoxia-induced decrease of AFC and ENaC activity were associated NF-κB pathway. A NF-κB inhibitor (QNZ, 1 mg/kg) was administered intraperitoneally to mice 1 h before the exposure to hypoxic condition (8% O2) for 24 h, and the effect of NF-κB inhibitor was assessed by AFC assay, n = 4–5. B The lung W/D ratio changed in QNZ-treated mice, n = 3–5. C Representative Isc traces of Control, Hypoxia and Hypoxia + QNZ group in mouse tracheal epithelium, and 1 mM amiloride was added to apical solution. D Statistic ASI, defined as the difference between the total current and the amiloride-resistant current, n = 3–4. *P < 0.05, **P < 0.01, ***P < 0.001, compared with Control group; &P < 0.05, &&P < 0.01, &&&P < 0.001, compared with Hypoxia group. One-way ANOVA followed by Bonferroni’s test was used to analyze the difference of the means for significance