Fig. 4
From: Submersion and hypoxia inhibit alveolar epithelial Na+ transport through ERK/NF-κB signaling pathway
Hypoxia-induced activation of NF-κB signaling pathway was downregulated by ERK inhibitor in A549 and AT2 cells. A–D Representative and statistical data of t-ERK1/2 and p-ERK1/2 after PD98059 (ERK inhibitor, 10 µM) treatment. E–H Representative and quantitative analyses of p-IκB/t-IκB. I–L Representative and quantitative analyses of p-p65/p65. *P < 0.05, **P < 0.01, ***P < 0.001, compared with Control group; &P < 0.05, &&P < 0.01, &&&P < 0.001, compared with Hypoxia group. One-way ANOVA followed by Bonferroni’s test was used to analyze the difference of the means for significance. n = 3–6