Skip to main content
Fig. 5 | Respiratory Research

Fig. 5

From: Elevated expression of macrophage MERTK exhibits profibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis

Fig. 5

Elevated macrophage MERTK exhibits pro-fibrotic effects and results in defective regulation of efferocytosis function in pulmonary fibrosis. A Macrophage MERTK exhibits profibrotic effects via increasing TGF-β expression in macrophages and collagen expression in lung fibroblasts. Macrophage MERTK enhances efferocytosis function by up-regulating Ucp2, which can lower macrophage mitochondrial membrane potential. Macrophage efferocytosis attenuates the profibrotic effect of MERTK by downregulating MERTK, forming a negative regulatory loop. B In pulmonary fibrosis, MERTK expression is abnormally increased in lung macrophages and the above negative regulatory loop is defective

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us