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Fig. 3 | Respiratory Research

Fig. 3

From: Correlation analysis of lung mucosa-colonizing bacteria with clinical features reveals metastasis-associated bacterial community structure in non-small cell lung cancer patients

Fig. 3

Correlation between community members of lung mucosa-colonizing bacteria and cancer markers in metastatic and non-metastatic NSCLC patients. Correlation heatmap between lung mucosa-colonizing bacteria and cancer markers (as environmental factors) in peripheral venous blood of metastatic (A) and non-metastatic (B) NSCLC patients. Correlations are positive (green) or negative (red) when R value is greater or less than 0, respectively. * 0.01 < P ≤ 0.05, ** 0.001 < P ≤ 0.01, *** P ≤ 0.001. Cancer markers include carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), cytokeratin-19-fragment (CYFRA21-1), carbohydrate antigen 125 (CA125), and squamous cell carcinoma antigen (SCCA). Two-way correlation network between lung mucosa-colonizing bacteria and cancer markers (as environmental factors) in peripheral venous blood of metastatic (C) and non-metastatic (D) NSCLC patients. Correlation network was constructed based on Pearson rank correlation coefficients (∣Pearson Coef∣ ≥ 0.5, P < 0.05). Lines connecting different nodes indicate positive (green) or negative (red) correlation between bacteria and immune cells. For metastatic and non-metastatic NSCLC patients n = 31 and 22, respectively. Correlation network and heatmap contain top 50 abundant bacteria. All bacteria were named to genus level unless noted otherwise in brackets

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Respiratory Research

ISSN: 1465-993X

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