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Fig. 8 | Respiratory Research

Fig. 8

From: Early events marking lung fibroblast transition to profibrotic state in idiopathic pulmonary fibrosis

Fig. 8

IPF fibroblasts express MOXD1. A MOXD1 expression peaks in Cluster-3 and is highly expressed in all IPF fibroblasts. B MOXD1 expression is specific for fibroblasts. C UMAP plot showing MOXD1 mRNA expression in all four fibroblasts clusters. D MOXD1 immunofluorescence staining in lung parenchyma frozen tissue, obtained from control and IPF lungs (×20 magnification, 50 µm). Red: MOXD1; green: PDGFRα (fibroblast marker); white: α-SMA (myofibroblast marker). E Velocity analysis of MOXD1 mRNA. F Histograms showing the cell distribution based on a Copper-Binding-Score. G UMAP plots of myofibroblast expressing genes

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Respiratory Research

ISSN: 1465-993X

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