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Fig. 1 | Respiratory Research

Fig. 1

From: Mitochondrial creatine kinase 1 regulates the cell cycle in non-small cell lung cancer via activation of cyclin-dependent kinase 4

Fig. 1

CKMT1 promotes the proliferation of NSCLC cells and the growth of NSCLC xenografts in nude mice. A–C The cell proliferation assays in PC9, A549 and H1299 cells by CCK8. D CKMT1 functional rescue assay in CKMT1-knockout (KO) A549 cells. E Tumor volume and tumor weight were measured in xenografts derived from induced CKMT1-overexpression H1299 cells. F Tumor volume and tumor weight were measured in Tet-on inducible sh-CKMT1 expression A549 models. Xenograft models were established via subcutaneous transplant of tumor sections derived from subcutaneous injection of doxycycline-inducible lung cancer cell lines expressing CKMT1 or shCKMT1. After solid tumors were established, the mice were administrated with sugar water containing Dox for inducing the corresponding CKMT1 or shCKMT1 expression. Blots and columns, mean; bars, standard deviation; *P < 0.05; **P < 0.01; ***P < 0.001

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