Pharmaceutical class | Withdrawal period |
---|---|
SABAs | ≥ 6 h |
SAMAs | ≥ 12 h |
SAMA/SABA combinations | ≥ 12 h |
SMART/MART | ≥ 12 h 1. SMART/MART reliever therapy and the use of (budesonide/formoterol) as a rescue therapy are permitted at investigator discretion 2. Total ICS dose resulting from permitted SMART/MART use must be recorded |
LABA-containing therapies | 1. Once daily: ≥ 24 h 2. Twice daily: ≥ 12 h |
LAMA-containing therapies | 1. Once daily: ≥ 24 h 2. Twice daily: ≥ 12 h |
LTRAs | ≥ 24 h |
Theophyllines | 1. Once daily: ≥ 24 h 2. Twice daily: ≥ 12 h |