Fig. 5
From: IRAK-M has effects in regulation of lung epithelial inflammation
Treatment with JNK or p38 MAPK inhibitor attenuated IRAK-M knockdown-mediated CXCL10 secretion upon stimulation in BEAS-2B cells. Expression of CXCL10 at both mRNA and protein level after PBS, SP600125 (SP, 20 μM) and SB203580 (SB, 10 μM) incubation for 2 h and a IL-1β (1 ng/ml), b TNF-α (10 ng/ml), c IL-33 (100 ng/ml) and d HDM (10 μg/ml) stimulation for 24 h. Values are expressed as mean ± SEM (n = 3). *P < 0.05. CON, si-control. KD, si-IRAK-M