Skip to main content

Table 3 Univariate and Multivariate logistic regression analysis of factors associated with MCID in CAT.

From: The impact of impaired sleep quality on symptom change and future exacerbation of chronic obstructive pulmonary disease

Variable

Univariate

Multivariate

Factors

OR

95%CI

P

-value

OR

95%CI

P

-value

Age (years)

1.013

0.991–1.036

0.245

   

Sex

(Male versus Female)

0.890

0.502–1.607

0.717

   

BMI (kg/m2)

0.958

0.895–1.025

0.216

   

Smoking state

      

Current smoker

Reference

 

Ex-smoker

1.386

0.774–2.477

0.271

   

Non-smoker

0.995

0.582–1.703

0.986

   

Biofuel exposure,

(Yes versus No)

1.364

1.126–1.579

0.000

1.102

1.009–1.214

0.036

Occupational exposure

(Yes versus No)

1.055

0.717–1.522)

0.786

   

CAT score

1.179

1.136–1.225

<0.001

1.372

1.274–1.477

<0.001

mMRC

(Median, IQR)

      

0–1

Reference

2–4

1.021

1.002–1.075

0.008

   

CCQ score

1.077

1.049–1.106

<0.001

   

GOLD group

      

 A

Reference

 

 B

2.413

1.616–2.907

0.000

   

 C

1.043

0.583–1.965

0.934

   

 D

1.921

1.423–2.214

0.001

   

Exacerbations

in the past year,

(Yes versus No)

1.321

0.914–1.908

0.139

   

Treatment

      

 LAMA

Reference

 

 LABA + ICS

1.011

0.521–1.961

0.975

   

 LABA + LAMA

1.988

1.216–3.496

0.011

   

 LABA + LAMA + ICS

1.894

1.148–3.125

0.012

   

PSQI ≤ 5

2.364

1.388–3.268

0.001

3.112

1.873–4.711

<0.001

Risk of OSAS

1.002

0.789–1.314

0.852

   

Anxiety

0.957

0.568–1.127

0.431

   

Depresion

1.018

0.498–1.637

0.612

   
  1. Notes: Age, sex, Biofuel exposure, CAT score ,mMRC score, CCQ score, GOLD group, OSAS, anxiety, depression, sleep quality and inhalation drug were included as the variables in the multivariate logistic regression model.
  2. Abbreviations: BMI, Body Mass Index; COPD, Chronic Obstructive Pulmonary Disease;GOLD, Global Initiative for Chronic Obstructive Lung Disease. ICS, inhaled corticosteroids; IQR, interquartile range; LABA, long-acting β-2-agonist; LAMA, long-acting muscarinic antagonist; mMRC, modified medical research council ; dyspnea scale; MCID, minimum clinically important difference; OSAS,obstructive sleep apnea syndrome ; PSQI, Pittsburgh sleep quality index.