Skip to main content
Fig. 9 | Respiratory Research

Fig. 9

From: Morphologically intact airways in lung fibrosis have an abnormal proteome

Fig. 9

The fibrotic honeycomb airway. Spatial proteomics reveal that the fibrotic uninvolved airway cells (found in regions of structurally intact lung) have an abnormal protein signature. The fibrotic uninvolved airway cells, like the honeycomb airway cells (a pathological feature of lung fibrosis), are over-represented in proteins associated with slits and Roundabout protein (Slit and Robo) pathway. The fibrotic honeycomb airway cells are further defined by increased pathways associated with mucin biogenesis, and a loss of both cilia and ECM organization/elastic fibres. We find that the mucus proteome is enriched with neutrophil degranulation pathway, with a marked increase of BPIFB1 protein

Back to article page