Fig. 8
From: Morphologically intact airways in lung fibrosis have an abnormal proteome
The mucus in usual interstitial pneumonia has distinct features from mucinous adenocarcinoma. A Venn diagram showing the proteins detected in the mucus of mucinous adenocarcinoma [MA] (n = 6 patients) or usual interstitial pneumonia (UIP; n = 6 patients). B 3-dimensional principal component analysis for each mucus type. C Volcano plot comparing the UIP mucus to mucinous adenocarcinoma mucus showing the negative natural log of the false discovery values (FDR) values plotted against the base 2 log (fold change) for each protein. D Immunofluorescence for MUC5B, MUC5AC, and BPIFB1 in UIP mucus (n = 4 patients) and mucinous adenocarcinoma mucus (n = 3 patients) with representative images shown for each disease type. White arrows points to regions of mucus accumulation and asterisk shows positivity of MUC5AC within UIP mucus. Scale bar represents 100 microns