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Fig. 2 | Respiratory Research

Fig. 2

From: Modulation of pulmonary immune function by inhaled cannabis products and consequences for lung disease

Fig. 2

Biosynthesis of cannabinoids and structural differences between Δ9-THC and CBD. Conversion of olivetolic acid to cannabigerolic acid (CBGA) occurs through the use of aromatic prenyltransferase. CBGA acts as the point of differentiation from which cannabinoid-specific FAD-oxidases (THCA synthase & CBDA synthase) convert CBGA to precursor cannabinoid acids. Subsequent decarboxylation of cannabinoid acids results in active cannabinoids. Δ9-THC forms a cyclic ring whereas CBD has a hydroxy group resulting three-dimensional structural differences

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Respiratory Research

ISSN: 1465-993X

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