Table 2 Cough frequency and severity, health-related quality-of-life: Changes from baseline and differences to placebo (Bayesian analyses)

a) 24-h cough frequency [%]

Placebo

− 6.3

93.7

(81.5; 108)

0.222

N/A

N/A-

N/A

N/A

20 mg

− 3.5

96.5

(80.9; 115)

0.365

3.0

103

(89.1; 119)

0.630

80 mg

− 22.5

77.5

(65.0; 92.7)

0.010

− 17.3

82.7

(71.6; 95.3)

0.015

150 mg

− 32.3

67.7

(56.9; 81.0)

< 0.001

− 27.7

72.3

(62.6; 83.4)

< 0.001

250 mg

− 41.3

58.7

(49.3; 70.3)

< 0.001

− 37.2

62.8

(54.2; 72.4)

< 0.001

b) Awake cough frequency [%]

Placebo

− 4.9

95.1

(83.2; 108)

0.266

N/A

N/A

N/A

N/A

20 mg

− 3.7

96.3

(81.4; 114)

0.356

1.0

101

(88.0; 117)

0.563

80 mg

− 21.9

78.1

(65.7; 92.5)

0.0111

− 17.9

82.1

(71.4; 94.4)

0.012

150 mg

− 33.8

66.2

(55.9; 78.6)

< 0.001

− 30.3

69.7

(60.4; 80.2)

< 0.001

250 mg

− 43.1

56.9

(48.0; 67.6)

< 0.001

− 40.1

59.9

(51.9; 69.0)

< 0.001

c) Cough severity (VAS) [mm]

Placebo

− 3.78

(− 9.87; 2.19)

0.148

N/A

N/A

N/A

20 mg

− 2.36

(− 9.85; 5.20)

0.302

1.44

(− 4.84; 7.68)

0.649

80 mg

− 11.8

(− 19.6; − 4.29)

0.007

− 8.05

(− 14.3; − 1.87)

0.017

150 mg

− 18.1

(− 25.8; − 10.5)

< 0.001

− 14.3

(− 20.7; − 8.03)

< 0.001

250 mg

− 24.6

(− 32.1; − 16.9)

< 0.001

− 20.8

(− 27.0; − 14.7)

< 0.001

d)

LCQ total score

Placebo

1.07

(− 0.02; 2.15)

0.055

1.73

(0.58; 2.86)

0.008

BAY

2.80

(1.71; 3.88)

< 0.001

LCQ physical domain score

Placebo

0.36

(0.03; 0.68)

0.035

0.54

(0.15; 0.94)

0.014

BAY

0.90

(0.57; 1.22)

< 0.001

LCQ psychological domain score

Placebo

0.38

(− 0.00; 0.77)

0.050

0.46

(0.03; 0.89)

0.040

BAY

0.85

(0.46; 1.23)

< 0.001

LCQ social domain score

Placebo

0.31

(− 0.13; 0.75)

0.116

0.74

(0.36; 1.12)

0.002

BAY

1.06

(0.63; 1.50)

< 0.001