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Fig. 8 | Respiratory Research

Fig. 8

From: Inhibition of fatty acid synthase protects obese mice from acute lung injury via ameliorating lung endothelial dysfunction

Fig. 8

Inhibition of FASN decreased endothelial inflammation in MLECs under metabolic stress when exposed to LPS. a–d The mRNA level of TNF-α, IL-6, and IL-1β in each group of MLECs were measured by qPCR (a, c). The secretion levels of TNF-α, IL-6, and IL-1β in the cell supernatant were measured by ELISA assay in each group of MLECs (b, d). One-way ANOVA and LSD or Games–Howell posthoc analysis. e, f The secretion levels of TNF-α, IL-6, and IL-1β in the cell supernatant were measured by ELISA assay in MLECs with FASN shRNA or NC shRNA under PA (e) or adipocytes (f) treatment when exposed to LPS. Student’s t test analysis. n = 3 biologically independent experiments. Data were represented as mean ± SD

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