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Fig. 6 | Respiratory Research

Fig. 6

From: Inhibition of fatty acid synthase protects obese mice from acute lung injury via ameliorating lung endothelial dysfunction

Fig. 6

Deficiency of FASN suppressed the p38 MAPK/NLRP3 signaling and increased VE-cadherin expression levels in MLECs under metabolic stress when subjected to LPS. a–f Representative western blots of FASN (a), p-p38 MAPK (a), p38 MAPK (a), NLRP3 (d), and VE-cadherin (d), and quantitative analysis of FASN (b), p-p38 MAPK/p38 MAPK (c), NLRP3 (e), and VE-cadherin (f) expression in each group of MLECs. n = 4 biologically independent experiments. Student’s t test analysis. g Representative immunofluorescence images of VE-cadherin expression in each group of MLECs. Scale bar: 50 μm. Data were represented as mean ± SD

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