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Fig. 5 | Respiratory Research

Fig. 5

From: Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p–HMGB1 axis

Fig. 5

Circ-YES1 knockdown impedes tumor development and metastasis in a nude mouse xenograft model. A Representative images of nude mouse xenografts after injection of H1650 cells. n = 6. B Tumors were measured every 5 days. n = 6. Data are presented as means ± SD. ***, P < 0.001 vs. NC. C Tumor weight was measured 30 d after grafting. Data are presented as means ± SD. ***, P < 0.001 vs. NC. D Immunohistochemical staining of Ki-67 in tumor specimens from both sh-NC and sh-circRNA groups. E and F Expression of miR-142-3p (E) and HMGB1 (F) by qPCR. n = 3. Data are presented as means ± SD. ***P < 0.001 vs. NC. G Whole-body images of mice showing tumor development and metastasis 5 weeks after injection of H1650 cells. (H and I) The numbers of metastatic foci in lung tissues were caculation according to the HE staining. The data are expressed as the mean ± SD. ***P < 0.001 vs NC

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Respiratory Research

ISSN: 1465-993X

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