Fig. 8

Representative histological images of the airway tissue samples across lung regions provided qualitative assessment of the effect of treatment. First row original scans are depicted in blue (denoted by 1: Original), and the second and third rows employed thresholding to enhance visualization and separate the collagen and elastin fibers into binary images (denoted by 2: Collagen Fibers and 2: Elastin Fibers). Red arrows indicate observed collagen fiber tears and fiber network gaps, and the red squares highlight sections of sparse elastin fiber content when contrasted to untreated counterparts