Table 1 PiRNA/PIWI complex as a biomarker in respiratory tract diseases
From: The emerging role of the piRNA/PIWI complex in respiratory tract diseases
PiRNA | Diseases | Expression | Function | References |
|---|---|---|---|---|
PiRNA-L-138 | Lung cancer | Up | Directly bond p60-MDM2 to induce apoptosis | [77] |
PiRNA-651 | Lung cancer | Up | Promoted cells and tumor proliferation and inhibited apoptosis by inducing cyclin D1 and CDK4 expression | [94] |
PiRNA-34871 | Lung cancer | Up | Correlated with RASSF1C expression, promoted cell proliferation by ATM-AMPK-p53-p21 pathway | [98] |
PiRNA-52200 | Lung cancer | Up | ||
PiRNA-35127 | Lung cancer | Down | ||
PiRNA-46545 | Lung cancer | Down | ||
PiRNA-L-163 | Lung cancer | Down | Directly bond with p-ERM | [76] |
PiRNA-55490 | Lung cancer | Down | Inhibited lung cancer cells and tumor proliferation by binding 3ʹUTR of mTOR messenger RNA | [73] |
PiRNA-63076 | PAH | Up | Increasing the methylation status of the Acadm promoter | [69] |
PIWIL2 | RILF | Up | Interacted with heat shot protein 90 | [74] |