A literature review of microRNA and gene signaling pathways involved in the apoptosis pathway of lung cancer

Respiratory Research

Table 3 Characteristics of miRNAs involved in apoptosis

Signaling pathway	miRNA name	Gene symbol	Gene description	Target Score	Number of 3P-seq tags supporting UTR + 5	Total context + + score
NF-κB	MiR-146b-5p	IRAK1	Interleukin 1 Receptor Associated Kinase 1	99	54	− 0.56
	MiR-146a-5p	TRAF6	TNF receptor associated factor 6	100	91	− 1.00
	MiR-21	Bcl-2	B-cell lymphoma 2	85	1380	− 0.12
PI3K/Akt	MiR-21	PIK3CA	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	87	112	− 0.21
	MiR-1269	PTEN	Phosphatase and tensin homolog	54	118	− 0.44
	MiR-23a			99	118	− 0.52
	MiR-181			67	118	− 0.18
	MiR-135a	Akt	AKT Serine/Threonine Kinase	70	525	− 0.21
	MiR-135a	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	89	1484	− 0.35
	MiR-30a-5p	PIK3CD	Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit Delta	93	5	− 0.09
	MiR-30a-5p	PIK3R2	Phosphoinositide-3-Kinase Regulatory Subunit 2	53	1484	− 0.07
MAPK	MiR-202	KRAS	KRAS Proto-Oncogene, GTPase	94	40	− 0.58
MAPK	MiR-181a	MAPK1	Mitogen-Activated Protein Kinase 1	79	630	− 0.16

ISSN: 1465-993X