Table 2 The involved miRNAs/Target Genes in apoptosis signaling pathway
miRNA | P-value | Targets |
|---|---|---|
hsa-miR-221-3p | 0.005 | APAF1,BBC3,BCL2L11,BMF,BNIP3,FOS,NAIP,TNFSF10 |
hsa-miR-125b-5p | 0.016 | BAK1,BBC3,BCL2,BCL2L2,BMF,CDKN2A,MCL1,TP53 |
hsa-miR-21-5p | 0.004 | APAF1,BCL2,CASP8, FAS,FASLG,IRAK1,MYD88,NFKB |
hsa-miR-181a-5p | 0.009 | BAX,BCL2,BCL2L11,FOS,MCL1,XIAP |
hsa-miR-146a-5p | 0.011 | CASP7,FADD,FAS,IRAK1,NFKB1, TRAF6 |
hsa-miR-139-5p | 0.001 | BCL2,FOS,JUN,MCL1,NFKB1 |
hsa-miR-181b-5p | 0.014 | BCL2,BCL2L11,FOS,MCL1,XIAP |
hsa-let-7g-5p | 0.003 | BCL2L1,CASP3,CDKN2A,TNFRSF10B |
hsa-miR-106b-5p | 0.026 | BCL2L11,CASP7,CASP8,TNFRSF10A |
hsa-miR-7-5p | 0.031 | BAX,BCL2,FOS,XIAP |
hsa-miR-133b | 0.037 | BCL2L1,BCL2L2,FAS,MCL1 |
hsa-miR-148a-3p | 0.041 | BAX,BCL2,BCL2L11,IKBKB |
hsa-miR-582-5p | 7.70e-4 | CASP3,CASP9,MCL1 |
hsa-miR-491-5p | 0.009 | BCL2L1,CAPNS1,TP53 |
hsa-miR-146b-5p | 0.012 | IRAK1,NFKB1,TRAF6 |
hsa-miR-708-5p | 0.020 | BCL2,BIRC5,CASP2 |
hsa-miR-149-5p | 0.026 | BBC3,FASLG,MYD88 |
hsa-miR-497-5p | 0.038 | BCL2,BIRC5,IKBKB |
hsa-let-7c-5p | 0.039 | BCL2L1,CASP3,TNFRSF10B |
hsa-miR-224-5p | 0.041 | BCL2,CASP3,CASP7 |
hsa-miR-339-3p | 0.002 | MCL1,NFKB1 |
hsa-miR-365a-3p | 0.019 | BAX,BCL2 |
hsa-miR-630 | 0.027 | BCL2,BCL2L2 |
hsa-miR-197-3p | 0.034 | BMF,PMAIP1 |
hsa-miR-33b-5p | 0.037 | BCL2,XIAP |
hsa-miR-363-3p | 0.038 | BCL2L11,CASP3 |
hsa-miR-301a-3p | 0.040 | BCL2L11,MAP3K5 |
hsa-miR-125b-1-3p | 0.044 | BIK,TP53 |
hsa-miR-30e-5p | 0.049 | CASP3,TP53 |