IAP | Mechanism of inhibition | Increased sensitivity to | Refs. | Drug | Mode of action | Refs. | The regulatory miRNAs | Refs. |
---|---|---|---|---|---|---|---|---|
XIAP | Antisense | Doxorubicin Taxol Vinorelbine Etoposide | [69] | AEG35156 | Antisense | [70] | miR-142 | [71] |
Embelin | Small molecule targeting BIR3 domain | [72] | miR-192-5p miR-215 | [73] | ||||
Polyphenylureas/Xantags | Small molecule targeting BIR2 domain | [74] | ||||||
Arylsulfonamides (TWX006, TWX024) | [75] | |||||||
siRNA | Cisplatin | [64] | ||||||
Survivin | siRNA | Adriamycin Cisplatin Paclitaxol | [76] [77] | LY2181308 | Antisense | [78] | miR-195 | [79] |
YM155 | Small molecule antagonist | [80] | miR-320 | [81] | ||||
Shepherdin | Small molecule targeting Hsp90 | [82] | miR-205 miR-218 | [83] | ||||
AICAR | [84] | |||||||
Anti-Survivin Ab | Antibody | [85] | miR-203 | [86] |