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Table 1 Pre-clinical data about IAP and IAP-based therapies in clinical trials

From: A literature review of microRNA and gene signaling pathways involved in the apoptosis pathway of lung cancer

IAP

Mechanism of inhibition

Increased sensitivity to

Refs.

Drug

Mode of action

Refs.

The regulatory miRNAs

Refs.

XIAP

Antisense

Doxorubicin

Taxol

Vinorelbine

Etoposide

[69]

AEG35156

Antisense

[70]

miR-142

[71]

Embelin

Small molecule targeting BIR3 domain

[72]

miR-192-5p

miR-215

[73]

Polyphenylureas/Xantags

Small molecule targeting BIR2 domain

[74]

Arylsulfonamides (TWX006, TWX024)

[75]

siRNA

Cisplatin

[64]

Survivin

siRNA

Adriamycin

Cisplatin

Paclitaxol

[76]

[77]

LY2181308

Antisense

[78]

miR-195

[79]

YM155

Small molecule antagonist

[80]

miR-320

[81]

Shepherdin

Small molecule targeting Hsp90

[82]

miR-205

miR-218

[83]

AICAR

[84]

Anti-Survivin Ab

Antibody

[85]

miR-203

[86]