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Table 2 Laboratory parameters at sampling of study groups

From: Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia

Variable median (IQR)

Normal range

COVID-19

CAP

Other sepsis

Adj. p-value

All

Moderate

Severe

Influenza

Bacterial

NP sepsis

Septic shock

(n = 10)

(n = 17)

(n = 11)

(n = 21)

(n = 18)

(n = 12)

C-reactive protein, mg/L

 < 3

104 (91–118)

203 (116–273)

60 (43–69)

139 (91–324)

107.5 (29.3–198.3)

131.5 (82.5–184)

*

Procalcitonin, µg/L

 < 0.5

0.40 (0.18–1.19)

0.52 (0.30–1.3)

0.2 (0.18–0.23)

0.63 (0.13–5.8)

5.1 (0.43–34)

39.0 (19.5–90)

***

Ferritin, µg/L

10–150

738 (474.5–1442.5)

1832.5 (934–2088)

N.A

N.A

N.A

N.A

N.A

d-dimer, mg/L

 < 0.56

0.71 (0.41–0.83)

2.3 (1.45–3.8)

N.A

N.A

N.A

N.A

N.A

Albumin, g/L

33–47

27 (22.5–29)

19 (18–22)

28.5 (24.8–32.8)

29.5 (26–32.3)

24 (20.5–29)

23 (22.3–30.5)

***

Creatinine, µmol/L

 < 90

67.5 (55–75.3)

73 (54–92)

70 (61–93.5)

93 (74–117)

108 (93.3–119.8)

182 (154–208.8)

***

Bilirubin, µmol/L

 < 26

6 (4–7.8)

9 (8–11)

6 (3–9)

14 (9–22)

22.5 (12.5–30)

14 (8.5–30.5)

***

Platelet count,  × 109/L

165–387

324 (190–367)

361 (230–432)

242 (168.5–274.5)

215 (193–251)

204.5 (149.5–257.3)

184 (111.8–262.8)

*

Neutrophil count,  × 109/L

1.6–5.9

5.4 (3.9–6.9)

10.9 (8.5–13.8)

9.4 (5.8–13.6)

10.0 (8.4–15.3)

9.2 (5.3–12)

9.2 (3.2–12.6)

 

Lymphocyte count,  × 109/L

1.1–3.5

1.2 (1–1.78)

0.8 (0.5–0.9)

0.9 (0.75–1.15)

0.9 (0.7–1.4)

0.55 (0.4–0.8)

0.5 (0.3–1.3)

*

Neutrophil to lymphocyte ratio

 

3.48 (3.04–5.85)

13.67 (11.9–21.8)

10.44 (6.25–15.58)

9.37 (6.42–22.28)

11.5 (7.25–17.22)

15.86 (7.38–32)

**

Leukocyte count,  × 109/L

3.5–8.8

7.7 (5.63–9.65)

12.5 (10.4–13.3)

11.6 (7–15.6)

12.0 (10.2–17.9)

11.9 (5.2–13.05)

11.8 (3.6–14.35)

 

Prothrombin complex, INR

 < 1.2

1.05 (1.0–1.1)

1.1 (1.0–1.2)

1.0 (1.0–1.1)

1.1 (1.0–1.2)

1.2 (1.0–1.4)

1.2 (1.15–1.3)

 
  1. ICU intensive care unit, HDU high dependency unit, INR international normalized ratio, CAP community acquired pneumonia, NP-Sepsis non-pneumonia sepsis, N.A. not available
  2. All data is displayed as median levels and IQR in each cohort. All p-values are adjusted and refer to Kruskal–Wallis test. Stars represent significance: *p-value < 0.05, **p-value < 0.01, ***p-value < 0.005. Numerical statistical results are available in Additional file 2: Table S1
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Respiratory Research

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