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Fig. 5 | Respiratory Research

Fig. 5

From: Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia

Fig. 5

Coagulation cascade-related proteins altered in COVID-19 and sepsis. A Coagulation cascade diagram displaying associated protein levels, boxplots are labeled with protein names and stars represent significance in comparison to healthy controls: *Adj. p-value < 0.05, **Adj. p-value < 0.01, ***Adj. p-value < 0.005. B Heatmap showing statistically significant correlations (Spearman’s ρ, Adj. p-value < 0.05) between clinical characteristics and coagulation-related proteins. The bigger circle size and higher colour intensity represent higher correlations. The arrows indicate correlation of a coagulation protein with SOFA respiratory and PaO2/FiO2 ratio (black), or INR (white). The coagulation cascade sketch was adapted from BioRender.com (2022), https://app.biorender.com/biorender-templates. AU arbitrary units

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