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Fig. 3 | Respiratory Research

Fig. 3

From: Targeting of G-protein coupled receptor 40 alleviates airway hyperresponsiveness through RhoA/ROCK1 signaling pathway in obese asthmatic mice

Fig. 3

DC260126 ameliorates histopathological changes in obese asthmatic mice. The number of total inflammatory cells in BALFs were calculated (A), and a minimum of 200 cells were employed to classify eosinophils (B), macrophages (C), neutrophils (D) and lymphocytes (E) after the last OVA challenge (n = 6). The data were presented as the mean ± S.E.M. *P < 0.05, **P < 0.01 and ***P < 0.001 compared with the control, #P < 0.05 and ##P < 0.01 compared with the HDF-OVA group. F Severity of inflammation cell infiltration in the peribronchiolar space was assessed by H&E staining, and semi-quantitative pathology scores among six groups were shown. G Lung sections were stained with Masson's trichrome stain for measurement of the subepithelial deposition of collagen and fibrosis, and staining analysis of collagen deposition was calculated (bar graph). H Lung sections were stained with PAS to assess goblet cell hyperplasia, and the percentage of PAS positive cells per bronchiole was calculated (histogram). The data were expressed as the mean ± S.E.M. (n = 6 per group). *P < 0.05, **P < 0.01 and ***P < 0.001 compared with the control, #P < 0.05 and ###P < 0.001 compared with the HDF-OVA group

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