Fig. 4

Transcript distributions of differential methylation loci (DML) in lung tissues. A Heatmap for differentially transcript expressions of DML between IUGR (n = 5) and control (n = 5) groups. B Gene ontology (GO) functional analysis on the transcripts of DML shows gene enrichment. The left side of the vertical axis is the percentage of transcript numbers, and the right side is the number of transcripts. C GeneRatio is the ratio of the transcripts of DML in the specific biologic process to the whole number of transcripts in all DMLs. Noted that the ubiquitin-dependent protein catabolic process had the highest abundance. D Gene set enrichment analysis (GSEA) of ubiquitin-dependent protein catabolic process. Running enrichment score (green curve) for the gene set. Grey line represents the location information of the sorted transcript set