Experimental weeks | 2w recovery | 18w recovery | ||||
---|---|---|---|---|---|---|
Treatment | PBS | CWAAP-A | CWAAP-B | PBS | CWAAP-A | CWAAP-B |
No. of animals examined | 6 | 8 | 8 | 6 | 8 | 8 |
Histopathological findings | Â | Â | Â | Â | Â | Â |
   Mediastinal lymph node |  |  |  |  |  |  |
      Lymphoid hyperplasia | 0 | 8*** | 8*** | 0 | 4* | 6** |
 |  |  < 2 >  |  < 2 >  |  |  < 1.3 >  |  < 1 >  |
   Lung |  |  |  |  |  |  |
      Deposition of test compound (AB-positive material) | 0 | 8*** | 8*** | 0 | 0 | 0 |
 |  |  < 1 >  |  < 1 >  |  |  |  |
     Inflammation, perivascular | 0 | 8*** | 8*** | 0 | 0 | 0 |
 |  |  < 1 >  |  < 1.4 >  |  |  |  |
      Granulomatous change, alveolar | 0 | 8*** | 8*** | 0 | 8*** | 8*** |
 |  |  < 2 >  |  < 1.6 >  |  |  < 1 >  |  < 1 >  |
     Hypertrophy/proliferation of alveolar epithelium | 0 | 8*** | 8*** | 0 | 8*** | 8*** |
 |  |  < 2 >  |  < 2 >  |  |  < 1.4 >  |  < 1.3 >  |
      Inflammation, air space | 0 | 8*** | 8*** | 0 | 8*** | 8*** |
 |  |  < 2 >  |  < 2 >  |  |  < 1 >  |  < 1 >  |
      Cholesterol cleft, air space | 0 | 0 | 0 | 0 | 8*** | 8*** |
 |  |  |  |  |  < 1 >  |  < 1 >  |
      Alveolitis | 0 | 0 | 0 | 0 | 8*** | 8*** |
 |  |  |  |  |  < 2 >  |  < 1.9 >  |
      Fibrous thickening, interstitial | 0 | 0 | 0 | 0 | 8*** | 8*** |
 |  |  |  |  |  < 1 >  |  < 1 >  |
      Accumulation of lipoproteinous material, air space | 0 | 8*** | 8*** | 0 | 0 | 0 |
 |  |  < 2.6 >  |  < 3 >  |  |  |  |
      Hyperplasia, bronchiolo-alveolar | 0 | 0 | 0 | 0 | 1 | 0 |
 |  |  |  |  |  < 1 >  |  |