Fig. 12

CWAAP-A or CWAAP-B (both administered at 1 mg/kg per dose) administered to male rats by repeated intratracheal instillations (see Additional file 2: Fig. S2C for details). Final body weights (A), left lung weights (B), mediastinal lymph node weights (C), total cell number in the BALF (D), alveolar macrophage number in the BALF (E), neutrophil number in the BALF (F), LDH activity in the BALF (G), SP-D level in the BALF (H), and SP-D level in the plasma (I) were measured at each sacrifice. Tukey’s multiple comparison tests were carried out for each sacrifice: *p < 0.05, **p < 0.01, and ***p < 0.001 indicate significant differences from the control (PBS) group, and ^#p < 0.05 and ^###p < 0.001 indicate significant differences between CWAAP-A and CWAAP-B