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Table 3 Characteristics of proteomics-driven subtype cohorts by using the discovery proteomics data

From: Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

 

COPD

Pa

COPD

COPD-BE

COPD-MD

N

19

9

12

 

Male, %

100

100

100

1.0

Smoking, %

100

100

100

1.0

Packyears ≥ 30, %

100

100

100

1.0

Age (years), mean (SD)

59.8

67.8

63.6

0.22

Height (cm), mean (SD)

167

164

165

0.54

Weight (kg), mean (SD)

87.3

53.1

85.7

0.17

BMI (kg/m2), mean (SD)

32.2

18.8

32.0

0.22

Fan in kitchen, %

17 (94.4)

8 (100)

12 (100)

1.00

Good room ventilation, %

13 (72.2)

1 (12.5)

2 (16.7)

0.002

Often preserved food, %

3 (16.7)

0

0

0.54

Often cook, %

5 (27.8)

3 (37.5)

3 (25)

0.88

Comorbidity, %

 CRD

6 (31.6)

3 (33.3)

4 (33.3)

0.99

 Hypertension

8 (42.1)

3 (33.3)

5 (41.7)

0.90

 Diabetes

4 (21.1)

1 (11.1)

1 (8.3)

0.85

 Heart diseases

6 (31.6)

3 (33.3)

5 (41.7)

0.84

 Stroke

2 (10.5)

0

0

0.71

Family history, %

 Cancer

3 (15.8)

0

0

0.30

 CRD without COPD

6 (42.8)

1.0 (11.1)

0

0.014

Severe COPD%

100

100

100

1.0

 pre_FVC_%Pred

81.1 (29.5)

53.2 (12.0)

63.4 (19.7)

0.19

 pre_FEV1_%Pred

69.8 (31.5)

24.1 (4.4)

41.0 (16.9)

0.025

 pre_FEV1/FVC_%Pred

81.8 (29.5)

53.2 (12.1)

63.4 (19.7)

0.19

 post_FVC_%Pred

77.5 (28.4)

64.0 (4.4)

71.7 (17.6)

0.69

 post_FEV1_%Pred

66.1 (29.1)

29.3 (7.3)

44.1 (18.1)

0.07

 post_FEV1/FVC_%Pred

77.5 (28.4)

64.0 (4.4)

71.7 (17.6)

0.69

  1. Bold values indicate significant differences
  2. CRD chronic respiratory disease, severe COPD Global Initiative for Obstructive Lung Disease stage 3–4, COPD-BE COPD co-existing with bronchiectasis, COPD-MD COPD co-existing with metabolic syndrome
  3. aP-values for a two-sided χ2 test or oneway-ANOVA, or Fisher’s exact test, non-parametric test.as appropriate. Data are median (P25–P75), n (%)
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Respiratory Research

ISSN: 1465-993X

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