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Table 2 Blood count of validation cohorts for targeted proteomics

From: Proteomics and metabolomics profiling reveal panels of circulating diagnostic biomarkers and molecular subtypes in stable COPD

 

COPDb

Controls

Pa

N

29

31

 

Male, %

100

100

1.0

Smoking, %

100

100

1.0

Pack_years ≥ 30, %

100

100

1.0

Severe COPD, %

100

0

–

White blood cells, WBC

7.55 (1.91)

6.76 (1.8)

0.11

Neutrophil ratio

62.15 (8.25)

59.67 (8.3)

0.25

Lymphocyte ratio

24.95 (7.54)

28.98 (7.52)

0.04

Monocyte ratio

8.77 (2.27)

7.77 (2.09)

0.09

Eosinophil ratio

3.47 (2.89)

2.88 (1.66)

0.34

Basophilic cell ratio

0.66 (0.24)

0.71 (0.23)

0.44

nucleated red cells ratio

0.21 (0.72)

0.10 (0.07)

0.42

Neutrophil count

4.59 (1.47)

4.05 (1.32)

0.15

Lymphocyte count

1.85 (0.8)

1.94 (0.78)

0.66

Monocyte countb

0.65 (0.28)

0.52 (0.15)

0.027

Eosinophil count

0.26 (0.27)

0.19 (0.13)

0.24

Basophil count

0.22 (0.94)

0.04 (0.05)

0.28

NRBC

5.59 (30.08)

0.01 (0.01)

0.31

Red blood cells, RBC

4.84 (1.0)

4.80 (0.51)

0.85

Hemoglobin, HGB

141.53 (16.42)

145.3 (11.13)

0.31

Hematocrit, HCT

3.29 (11.02)

3.19 (10.43)

0.97

Mean corpuscular volume, MCV

97.17 (47.81)

94.64 (8.52)

0.77

Mean hemoglobin content, MCH

29.45 (4.33)

30.54 (3.16)

0.27

Mean hemoglobin concentration, MCHC

326.9 (10.73)

322.4 (11.9)

0.13

RDW-SD

43.94 (4.89)

43.99 (3.39)

0.96

RDW-CV

14.14 (1.08)

13.56 (1.06)

0.04

Platelet, PLT

255.9 (57.97)

236.1 (60.46)

0.20

Mean platelet volume, MPV

8.14 (1.04)

8.76 (0.94)

0.019

PDW

16.50 (1.2)

16.19 (1.65)

0.41

PCT

0.21 (0.04)

0.20 (0.05)

0.97

  1. CRD chronic respiratory disease, RDW-SD standard deviation of RBC distribution width, RDW-CV coefficient variation of RBC distribution width, PDW platelet distribution width, PCT thrombocytocrit, NRBC nucleated red cells absolute value, severe COPD Global Initiative for Obstructive Lung Disease stage 3–4
  2. In bold is P < 0.05
  3. aP values for a two-sided χ2 test or t-test. Data are median (P25–P75), n (%)
  4. bCOPD patients exhibited significantly higher monocytes than healthy subjects