Table 1 Demographic and baseline characteristics
Control (n = 72) | Prostacyclin (n = 72) | |
|---|---|---|
Age, mean ± SD, years | 56.0 ± 14.0 | 61.1 ± 14.4* |
Weight, mean ± SD, kg | 93.6 ± 20.7 | 93.3 ± 23.8 |
Height, mean ± SD, cma | 174.4 ± 9.2 | 174.4 ± 9.2 |
Body Mass Indexa | 30.8 ± 6.5 | 30.7 ± 7.7 |
Male | 55 (76%) | 53 (74%) |
Female | 17 (24%) | 19 (26%) |
Causes of ARDS | ||
SARS-CoV2 | 52 (72%) | 49 (68%) |
Aspiration | 3 (4%) | 4 (6%) |
Viral pneumonia (HSV etc.) | 2 (3%) | 1(1%) |
Bacterial pneumonia | 1 (1%) | 5 (7%) |
Sepsis | 6 (8%) | 4 (6%) |
Pancreatitis | 2 (3%) | 1 (1%) |
Thoracic trauma | 1 (1%) | 2 (3%) |
Other | 5 (7%) | 6 (8%) |
Comorbidities, no. (%) | ||
Hypertension | 37 (51%) | 33 (46%) |
Unknown | 4 (6%) | 3 (4%) |
Diabetes | 24 (33%) | 17 (24%) |
COPD | 1 (1%) | 10 (14%)** |
OSAS | 4 (6%) | 3 (4%) |
Asthma | 5 (7%) | 2 (3%) |
Sarcoidosis | 1 (1%) | 0 (0%) |
Emphysema | 0 (0%) | 4 (6%)*** |
Interstitial lung disease | 0 (0%) | 1 (1%) |
Tumor | 1 (1%) | 3 (4%) |
LAE | 1 (1%) | 2 (3%)** |
Chronic kidney disease (GFR < 60) | 5 (7%) | 5 (7%) |
Cardiac disease | 11 (15%) | 16 (22%) |
Obesity | 12 (17%) | 12 (17%) |
Transplantation | 2 (3%) | 0 (0%) |
HIV | 1 (1%) | 0 (0%) |
Immune suppression | 5 (7%) | 2 (3%) |
Psychiatric diseases | 4 (6%) | 12 (17%)* |
Neurological diseases | 11 (15%) | 7 (10%) |
Liver disease | 5 (7%) | 3 (4%) |
Coagulopathy | 0 (0%) | 3 (4%) |
Tumor (anamnestic) | 2 (3%) | 7 (10%) |
OSAS | 4 (6%) | 3 (4%)** |
SOFA admission score, mean ± SDb | 10.8 ± 3.2 | 10.8 ± 3.7 |
Reasons for ICU admission | ||
Medical | 62 (86%) | 60 (83%) |
Surgery | 4 (6%) | 2 (3%) |
Emergency surgery | 6 (8.3%) | 10 (14%) |
Treatments used in COVID-19 patients | ||
Steroids* | 43 (68.3%) | 31 (50.8%) |
IL-6 antibodies* | 12 (19.0%) | 11 (18.0%) |
Remdesivir* | 37 (58.7%) | 24 (39.3%) |