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Table 3 Differences in the LFT between 3 and 12 months depending on ICU admission

From: Evolution and long‑term respiratory sequelae after severe COVID-19 pneumonia: nitric oxide diffusion measurement value

Variables

All patients

Non ICU

ICU

P

Spirometry

N = 194

N = 161

N = 33

 

Change in FVC, % of predicted

7 (5–13)

7 (0–12)

8 (2.5–15.5)

0.14

Change in FEV1, % of predicted

5 (− 1–11)

5 (− 1–11)

7 (0.5–13.5)

0.16

Gas difusión

N = 187

N = 156

N = 31

 

Change in DLNO, % of predicted

5 (− 1–11)

4 (− 1–11)

7 (3–11)

0.02

Change in DLCO, % of predicted

8 (1–14)

7 (0–12.2)

11 (6.5–17)

0.01

Change in VA, % of predicted

10 (3–15)

10 (6–14)

13 (8–16.5)

0.03

Change in KNO, % of predicted

− 5 (− 8–1)

− 5 (− 8–2)

− 4 (− 6–1)

0.13

Change in KCO, % of predicted

− 2 (− 6–2)

− 2 (− 6–2)

0 (− 5–4)

0.15

Change in DMCO, % of predicted

1 (− 3–10)

1 (− 4–9)

6 (0–10.5)

0.04

Change in DMCO/VA, % of predicted

− 6 (− 12–0)

− 6 (− 12–0)

− 5 (− 9–2)

0.16

Change in Vc, % of predicted

9 (2–16)

8.5 (2–15)

9 (4–18)

0.40

Change in Vc/VA, % of predicted

− 1 (− 7–7)

− 1 (− 7–6.5)

− 1 (− 9–7)

0.98

Change in DLNO/DLCO

− 0.13 (− 0.20–0.00)

− 0.13 (− 0.31–0.01)

− 0.14 (− 0.27–0.01)

0.90

Change in DMCO/Vc

− 0.08 (− 0.25–0.07)

− 0.09 (− 0.28–0.07)

− 0.25 (− 0.22–0.09)

0.42

Exercise capacity (6MWT))

N = 172

N = 143

N = 29

 

Change in walking distance, m

49.5 (7.2–87.7)

44 (3–80)

77 (33–121)

0.03

Difference initial oxygen saturation, %

− 1 (− 1–0)

− 1 (− 1–0)

− 1 (− 1–0)

0.90

Difference final oxygen saturation, %

0 (− 1.7–1)

− 1 (− 2–1)

0 (− 1–1)

0.30

  1. Median (25th and 75th percentile). Mann–Whitney test
  2. LFT lung function testing, ICU intensive care unit, FVC forced vital capacity, FEV1 forced expiratory volume in first one second, DLNO diffusion capacity of nitric oxide, DLCO diffusion capacity of carbon monoxide, VA alveolar lung volume, KNO rate of uptake of nitric oxide from alveolar gas, KCO rate of uptake of carbon monoxide from alveolar gas, DMCO membrane conductance of carbon monoxide, Vc pulmonary capillary blood volume, 6MWT six-minute walk test