Fig. 6
From: Vascular and pulmonary effects of ibuprofen on neonatal lung development
Representative lung sections stained for HE (A–D), or α smooth muscle actin (αSMA; E–H) of rat pups kept in room air (RA; A, B, E and F) or 100% O2 (C, D, G and H). Pups were injected daily with arginine buffer (A, C, E and G) or ibuprofen (50 mg/kg/day: B, D, F and H) until 10 days of age. a = alveolus. Lung morphometry, including the quantification of mean linear intercept (MLI, I), septal thickness (J), and arterial medial wall thickness (K), was determined on paraffin sections from rat pups on day 10. RA pups (open symbols) and O2 pups (solid symbols) were injected daily with arginine buffer (circles) or ibuprofen (50 mg/kg/day; triangles) until 10 days of age. Values are expressed as mean ± SEM (N = 6–7). ***p < 0.001versus RA controls. &&p < 0.01 and &&&p < 0.001 versus age-matched arginine buffer-treated O2-exposed controls