Responsiveness to pulmonary rehabilitation in COPD is associated with changes in microbiota

Respiratory Research

Table 3 Summary table of significant linear mixed effect models established to assess differences in microbiota dynamics between responders and non-responders to dyspnoea, exercise capacity and impact of the disease

OTUs/ASVs longitudinal dynamics	Test's statistics	p-value (TP:Group)
Response to dyspnoea during exercise (Borg Modified Scale of Dyspnoea) MCID: − 1 point
Spirochaetes	2.33	0.046
TM7	5.40	0.000
Oribacterium	2.68	0.024
Dialister	2.69	0.023
Schwartzia	2.55	0.036
[Mogibacteriaceae]	2.45	0.036
Bulleidia	3.08	0.011
Treponema	2.33	0.046
Response to exercise capacity (6-min walk test) MCID: + 25 m
Lautropia	2.87	0.017
Response to impact of the disease (COPD assessment test) MCID: -2 points
d0b698c7298bf04110a6d2f220879bfb: Prevotella melaninogenica	2.58	0.029

Models were produced based on the longitudinal relative frequencies of phyla, genera, a5189f77a2cfeab3bc1602ff5c8ac3e9 and d0b698c7298bf04110a6d2f220879bfb. Data upon relative frequencies was transformed with arcsine and square root transformation. TP: time-point

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