Fig. 3
From: Responsiveness to pulmonary rehabilitation in COPD is associated with changes in microbiota
Responders and non-responders present distinct microbiota profiles prior to pulmonary rehabilitation. A Mean frequency of phyla and genera of bacteria present in Responders (R) and non-responders (NR) to dyspnoea, exercise capacity and impact of the disease. B R and NR to dyspnoea showed distinct microbiota composition prior to PR (PERMANOVA, p = 0.04). PCoA analysis using Emperor on Weighted UniFrac distance. The biplot (grey arrows) represent the 3 most relevant ASVs for R and NR segregation. Prevotella melaninogenica (ASV: d0b698c7298bf04110a6d2f220879bfb) was the major contributor for segregation of R and NR followed by Veillonella dispar (ASV: 5608c3e6c9de9ceb79610e7786bd0ac) and Haemophilus parainfluenzae (ASV: e27680d4009f98f30248d823bc17fb8e). In blue is represented the area where samples presented a mean frequency of P. melaninogenica below the average of the dataset. 78% of R showed reduced mean frequencies of P. melaninogenica prior to PR while only 37% of NR followed the same trend. C Cladogram highlighting differentially abundant genera between R and NR to dyspnoea prior to PR, inferred by linear discriminant analysis (LEfSe) at a significance cut-off of 3. Prevotella is significantly enriched in NR to dyspnoea, with an effect-size of 9