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Table 3 Multivariable analysis of overall survival (OS) by Cox regression (n = 229)

From: The impact of diagnostic delay on survival in alpha-1-antitrypsin deficiency: results from the Austrian Alpha-1 Lung Registry

Variable

HR

95% CI

p value (Cox regression)

Diagnostic delay (years)*—continuous

1.61

1.09–2.38

0.016

Body mass index (BMI; kg/m2)—continuous

0.86

0.73–1.00

0.049

Age (years)—continuous

1.07

1.02–1.12

0.009

Active smoking at time of inclusion into registry

No

1.00

0.006

Yes

11.54

2.02–65.83

Forced expiratory volume in 1 s (FEV1) in % of the expected value

> 50

1.00

0.141

≤ 50

3.23

0.68–15.36

Long-term oxygen therapy at inclusion into registry

No

1.00

0.107

Yes

2.33

0.83–6.50

  1. *After logarithmic transformation (using natural logarithm)
  2. BMI body mass index, CI confidence interval, FEV1 forced expiratory volume in 1 s, HR hazard ratio