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Fig. 3 | Respiratory Research

Fig. 3

From: Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model

Fig. 3

NETs degradation attenuates heart and kidney failure in a COVID-19 experimental model. K18-hACE2 mice (n = 6) were intranasally (i.n) inoculated with SARS-CoV-2 (2 × 104 PFU) and treated with DNase I (10 mg/kg, s.c) for 5 days. Representative H&E staining from the heart (a) and kidney (c) of mock, SARS-CoV-2-infected mice and treated with DNase I. Serum levels of creatine kinase-MB (CK-MB) (b) and creatinine (d) determined by colorimetric assays. Data are representative of two independent experiments and are shown as mean ± SEM. P values were determined by one-way ANOVA

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