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Fig. 2 | Respiratory Research

Fig. 2

From: Targeting neutrophils extracellular traps (NETs) reduces multiple organ injury in a COVID-19 mouse model

Fig. 2

Pharmacological degradation of NETs ameliorates lung pathology upon SARS-CoV-2 infection in vivo. K18-hACE2 mice (n = 6) were intranasally (i.n) inoculated with SARS-CoV-2 (2 × 104 PFU) and treated with DNase I (10 mg/kg, s.c) for 5 days. a Representative H&E staining from the lung of mock or SARS-CoV-2-infected mice and treated with DNase I. b Pearson correlation between the area fraction and NETs concentration in lung homogenate. The total septal area and the total lung area were quantified using the Pro Plus 7 software (Media Cybernetics, Inc., MD, USA). The ratio between total septal area and the total lung area was expressed as area fraction (%). c an ELISA assay was performed to detect TNF-α, IL-6, IL-10, CXCL-1, CCL-2, and CCL-4 levels from the lung. Data are representative of two independent experiments and are shown as mean ± SEM. P values were determined by one-way ANOVA

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