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Table 3 Multivariable MR for VTE on lung function (orientate to exposure VTE)

From: Genetic association and causal inference between lung function and venous thromboembolism

Exposure

nSNPs

OR (95% CI)

Beta (SE)

P

Intercept (P)

Q_Pval (I2)

PRESSO (global P)

VTE vs. FEV1

    

− 0.004 (0.246)

0.172 (0.287)

0.375

 mvIVW

13

1.039 (0.943–1.375)

0.130 (0.096)

0.173

 mvMR-Egger

13

1.120 (0.910–1.378)

  

DVT vs. FEV1

    

 mvIVW

13

0.955 (0.869–1.049)

− 0.046 (0.048)

0.338

 mvMR-Egger

13

0.966 (0.865–1.078)

  

PE vs. FEV1

    

 mvIVW

13

0.921 (0.848–1.000)

− 0.082 (0.042)

0.050

 mvMR-Egger

13

0.920 (0.844–1.003)

  

VTE vs. FVC

       

 mvIVW

13

1.124 (0.915–1.381)

0.117 (0.105)

0.266

 mvMR-Egger

13

1.067 (0.860–1.324)

  

DVT vs. FVC

    

 mvIVW

13

0.956 (0.862–1.061)

− 0.045 (0.053)

0.400

0.004 (0.197)

0.072 (0.415)

0.287

 mvMR-Egger

13

0.988 (0.882–1.107)

     

PE vs. FVC

    

 mvIVW

13

0.931 (0.850–1.018)

− 0.072 (0.046)

0.115

 mvMR-Egger

13

0.931 (0.852–1.016)

     

VTE vs. FEV1/FVC

    

0.004 (0.063)

0.732 (0.000)

0.867

 mvIVW

14

1.099 (0.937–1.288)

0.094 (0.081)

0.246

 mvMR-Egger

14

1.039 (0.876–1.232)

  

DVT vs. FEV1/FVC

    

 mvIVW

14

0.973 (0.898–1.055)

− 0.027 (0.041)

0.516

 mvMR-Egger

14

1.007 (0.922–1.099)

  

PE vs. FEV1/FVC

    

 mvIVW

14

0.939 (0.877–1.006)

− 0.063 (0.035)

0.074

 mvMR-Egger

14

0.943 (0.878–1.012)

  

VTE vs. PEF

    

0.002 (0.438)

0.084 (0.375)

0.269

 mvIVW

15

1.057 (0.855–1.306)

0.055 (0.108)

0.612

 mvMR-Egger

15

1.024 (0.814–1.288)

  

DVT vs. PEF

    

 mvIVW

15

0.996 (0.894–1.109)

− 0.004 (0.055)

0.935

 mvMR-Egger

15

1.014 (0.899–1.143)

  

PE vs. PEF

    

 mvIVW

15

0.950 (0.867–1.042)

− 0.051 (0.047)

0.277

 mvMR-Egger

15

0.953 (0.868–1.047)

  
  1. FEV1 forced expiratory volume in one second; FVC forced vital capacity; FEV1/FVC the ratio of FEV1 to FVC; PEF peak expiratory flow; VTE venous thromboembolism; DVT deep vein thrombosis; PE pulmonary embolism; SNP single nucleotide polymorphism; OR odds ratio; CI confidence interval; SE standard error; mvIVW multivariable inverse-variance weighted; PRESSO pleiotropy residual sum and outlier