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Table 1 Summary information of GWAS data and instrumental variables used in our analyses

From: Genetic association and causal inference between lung function and venous thromboembolism

Exposures

Outcomes

Traits

Sample size

Source

Year

Trait transformation

Trait

nIVs

R2

F_statistic

Power

FEV1

400,462

UKBB & SpiroMeta

2019

Raw, in liter

VTE

209

0.030

13,238.190

0.350

     

DVT

209

0.030

13,238.190

0.300

     

PE

213

0.031

13,373.943

0.080

FVC

400,462

UKBB & SpiroMeta

2019

Raw, in liter

VTE

189

0.029

11,468.368

0.240

     

DVT

192

0.029

11,489.334

0.740

     

PE

191

0.028

11,396.694

0.050

FEV1/FVC

400,462

UKBB & SpiroMeta

2019

Raw, in liter

VTE

236

0.055

22,562.624

0.130

     

DVT

235

0.056

22,383.280

0.200

     

PE

240

0.057

22,748.353

0.170

PEF

400,462

UKBB & SpiroMeta

2019

Raw, in liter

VTE

166

0.034

13,537.796

0.050

     

DVT

168

0.034

13,679.262

0.050

     

PE

168

0.034

13,679.262

0.070

VTE

9176/209,616

FinnGen Study

2021

Case control

FEV1

8

0.077

15,846.433

–

     

FVC

9

0.134

30,183.011

–

     

FEV1/FVC

11

0.144

32,396.142

–

     

PEF

9

0.015

3312.630

–

DVT

4576/214,216

FinnGen Study

2021

Case control

FEV1

5

0.185

44,289.920

–

     

FVC

5

0.185

44,289.920

–

     

FEV1/FVC

6

0.195

46,644.481

–

     

PEF

6

0.195

46,644.481

–

PE

4185/214,607

FinnGen Study

2021

Case control

FEV1

5

0.264

66,459.527

–

     

FVC

5

0.264

66,459.527

–

     

FEV1/FVC

5

0.264

66,459.527

–

     

PEF

5

0.264

66,459.527

–

  1. FEV1 forced expiratory volume in one second; FVC forced vital capacity; FEV1/FVC the ratio of FEV1 to FVC; PEF peak expiratory flow; VTE venous thromboembolism; DVT deep vein thrombosis; PE pulmonary embolism; nIVs number of instrumental variables; R2 variance explained by the SNPs on exposure