Fig. 5
From: Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles
smRNA-seq shows differential miRNA composition of smRNAs between healthy and diseased sEVs. A Overlap of miRNAs detected in NHBE sEVs and DHBE sEVs. B Volcano plot showing differential miRNA expression between NHBE and DHBE-derived sEVs. C Heat map detailing expression differences of miRNA between NHBE and DHBE-derived sEVs. D KEGG pathway analysis of differential sEVs. E GO pathway analysis of differential sEVs.F–I smRNA-seq expression values and confirmation via qPCR of candidate miRNA within NHBE and DHBE derived sEVs: F miR411, G miR137, H miR195, I miR7. J–M Significantly differentially expressed miRNA showing links between miRNA and senescent genes and pathways based on Qiagen IPA data and literature. J miR411, K miR137, L miR195, M miR7. * and red points on volcano plot: p or p.adj < 0.05, Mann–Whitney test