Fig. 4
From: Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles
smRNA-seq shows very different composition of smRNAs between cells and sEVs. A Percentage of different subsets of smRNA in cells and sEVs, showing widely differing composition (other = other types of smRNA) B Volcano plot (log p vs log fold change) showing 747 miRNA variables were found in this complete dataset. C IsomiR% (variants of miRNA) and M Seq (sequence count) showing differences in profiles between cells and sEVs and higher variability in sEV samples. D Overlap of miRNAs between sample sets. E Heat map showing expression level differences between sEVs and cells, including NHBE and DHBEs. F Overlap of miRNAs detected in NHBE cells and NHBE sEVs. G Volcano plot showing differential miRNA expression between NHBEs and their derived sEVs. H Overlap of miRNAs detected in DHBE cells and DHBE sEVs. I Volcano plot showing differential miRNA expression between DHBE cells and their derived sEVs. N = 5–6. Red p.adj < 0.05