Skip to main content
Fig. 3 | Respiratory Research

Fig. 3

From: Epithelial senescence in idiopathic pulmonary fibrosis is propagated by small extracellular vesicles

Fig. 3

sEVs act as part of the SASP and transfer senescence to healthy ALI cultures. A, B IL6 levels in basal media and apical PBS wash increased with DHBE-derived sEV addition. C, D IL8 levels in basal media and apical PBS wash increased with DHBE-derived sEV addition. E, F Increases in p21 and p16 gene expression upon addition of DHBE-derived sEVs. Gene normalisation to GAPDH for δδCT and graphs show fold change relative to untreated control group. G Percentage change in TEER with the addition of DHBE-derived sEVs. N = 6. Each colour represents a different donor and experiment. Significant differences between groups shown **p < 0.01; *p < 0.05, Wilcoxon test and Friedmans test

Back to article page