Fig. 1
From: Activation of NLRP3 inflammasome in lung epithelial cells triggers radiation-induced lung injury
The different response pattern between lung epithelial cells and lung cancer cells after radiation. A Number of differentially expressed genes in BEAS-2B, H446 and A549 after radiation (n = 3). B The volcano plot shows the differentially expressed genes in BEAS-2B, H446 and A549 (n = 3). C GSEA analysis of signaling pathways affected by radiation in BEAS-2B and H446 (n = 3). D GSEA plots showing the enrichment of the inflammatory response pathway in the irradiated BEAS-2B (n = 3). E Heatmap showing the change of core genes enriched in the inflammatory response pathway (n = 3). F PPI analysis showing that the NLRP3/IL-1β axis was at the center of the top 44 genes enriched in the inflammatory response pathway (n = 3). G Representative images of IHC staining for NLRP3 in serial sections of organizing pneumonia and normal lung tissue. Scale bar, 100 μm. GSEA gene set enrichment analysis; PPI protein–protein interaction, IL interleukin, IHC immunohistochemistry