Fig. 3
From: SLC38A6 expression in macrophages exacerbates pulmonary inflammation
Slc38a6 deficiency protects mice from sepsis-associated pulmonary inflammation. A IHC for Slc38a6 in lung tissue between Slc38a6+/− and Slc38a6−/− mice. Survival rate B and clinical scores (C, D) between Slc38a6+/− and Slc38a6−/− group (n = 11). HE staining samples (E) of lung tissue between Slc38a6+/− and Slc38a6−/− group (n = 3) and the histological scores (F) of inflammatory cell infiltration (n = 7 or 9). Blood monocyte percentage (G) and MFI of blood monocyte iNOS at 24 h post injection (H) (n = 7 or 9). Macrophage percentage in BALF (I) and splenocytes (J) at 72 h post injection (n = 5). K IL-1β, TNF-α concentration in serum between Slc38a6+/− and Slc38a6−/− group at 24 h post injection (n = 7 or 9). Data are presented as mean ± SEM of independent experiments. *p < 0.05 and **p < 0.01