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Table 4 Multivariate analysis for PRMfSAD

From: Principal component analysis of flow-volume curves in COPDGene to link spirometry with phenotypes of COPD

 

Entire spectrum (n = 6302)

Mild COPD (n = 567)

Moderate−severe COPD (n = 2826)

Adjusted R2 = 0.60

Adjusted R2 = 0.20

Adjusted R2 = 0.48

β

P-value

β

P-value

β

P-value

Age

2.73

 < 0.001

3.33

 < 0.001

2.13

 < 0.001

Sex

 − 1.24

 < 0.001

 − 1.12

0.03

 − 0.96

 < 0.001

Height

0.63

 < 0.001

1.21

0.03

0.70

0.01

Weight

 − 1.53

 < 0.001

 − 1.68

 < 0.001

 − 1.93

 < 0.001

Pack-years

0.61

 < 0.001

0.30

0.40

0.56

0.002

PC1

 − 7.14

 < 0.001

 − 2.35

 < 0.001

 − 2.54

 < 0.001

PC2

 − 5.10

 < 0.001

 − 2.63

 < 0.001

 − 6.79

 < 0.001

PC3

1.11

 < 0.001

0.88

0.03

2.68

 < 0.001

PC4

 − 0.66

 < 0.001

 − 0.52

0.17

0.69

0.01

  1. COPD, Chronic Obstructive Pulmonary Disease; PC, principal component